Misoprostol-Only Medical Abortion: When and How It is Used
While the combination of Mifepristone and Misoprostol is the international gold standard with a 98% success rate, the World Health Organization (WHO) also recognizes a dedicated Misoprostol-only regimen as a safe and effective clinical alternative when Mifepristone is inaccessible.
WHO Misoprostol-Only Clinical Regimen
The recommended protocol for early medical abortion using Misoprostol alone consists of 800 micrograms (mcg) administered sublingually (under the tongue) or buccally (between gums and cheek) every 3 hours for a total of 2 to 3 doses. This induces the uterine contractions necessary to empty the uterus safely.
Efficacy & Side Effects: Misoprostol alone has an 85–90% success rate. However, it often involves more cramping, nausea, and diarrhea than the combined Mifepristone + Misoprostol treatment. That is why Astra provides the combined kit whenever possible.